This applet is used to simulate the activation of human ventricular epicardial myocytes using the six-variable reduced Priebe and Beuckelmann model by O. Bernus, R. Wilders, C.W. Zemlin, H. Verschelde and A.V. Panfilov (Am. J. Physiol. 282: H2296-H2308, 2002)

Using the applet, the myocyte can be paced at various cycle lengths and the final APD and DI are calculated automatically. In addition, it is possible to visualize the currents, gate variables, and ionic concentrations.

N(S1's) indicates how many S1 stimuli to apply.
• S1 (bcl) indicates the cycle length for the S1 stimuli.
• S2 (bcl) indicates the cycle length for the S2 stimulus.

Click "Start" to start the simulation. Use "Replot" to replot on the screen once a check box has been selected or a new value has been entered for S1, S2 or N. Use "Plot Currents" to plot the various currents of the model.

Things to try:

• To calculate points on APD restitution curves, change N, S1, and S2.
• Click in the Ascii check box to obtain the voltage signal as a function of time. (Note that the larger the signal, the longer it takes for the window to appear.)